Integrin Structure, Activation, and Interactions
نویسندگان
چکیده
منابع مشابه
Membrane-proximal / stalk interactions differentially regulate integrin activation
integrin activation. Tetsuji Kamata*, Makoto Handa , Yukiko Sato*, Yasuo Ikeda‡, and Sadakazu Aiso* From the Departments of Anatomy*, Transfusion Medicine and Cell Therapy†, and Internal Medicine‡, Keio University School of Medicine, Tokyo160, Japan Running title: Membrane-Proximal Interactions in Integrin Activation. Address correspondence to: Tetsuji Kamata, Department of Anatomy 3S1, Keio Un...
متن کاملIntegrin activation and structural
141 Summary: Among adhesion receptor families, integrins are particularly important in biological processes that require rapid modulation of adhesion and de-adhesion. Activation on a timescale of 1s of b2 integrins on leukocytes and b3 integrins on platelets enables deposition of these cells at sites of inflammation or vessel wall injury. Recent crystal, nuclear magnetic resonance (NMR), and el...
متن کاملIntegrin activation
Integrins are cell surface adhesion receptors that participate in a variety of important processes throughout the vasculature. Here we summarize some recent findings on the regulation of integrin mediated cellular adhesion. Particular emphasis is placed on the regulation of integrin affinity for ligand (activation), although this is just one mechanism by which regulation of integrin-dependent c...
متن کاملIntegrin Structure and Function
Abstract Integrins are a large family of heterodimeric glycoprotein receptors first discovered over twenty years ago. They exist as two noncovalently bound aand bsubunits that function as adhesion molecules and play key roles in many biological processes including actin cytoskeleton organization and transduction of intracellular signals regulating cellular functions. Integrins bind a variety of...
متن کاملInteractions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation.
Clustering and occupancy of platelet integrin alpha(IIb)beta(3) (GPIIb-IIIa) generate biologically important signals: conversely, intracellular signals increase the integrins' affinity, leading to integrin activation; both forms of integrin signaling play important roles in hemostasis and thrombosis. Indirect evidence implicates interactions between integrin alpha and beta transmembrane domains...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2011
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a004994